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An Updated Review on Monkeypox Viral Disease: Emphasis on Genomic Diversity
Ali A Rabaan1,2,3, Nada A Alasiri4, Mohammed Aljeldah5
1Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
Biomedicines
|July 29, 2023
Summary
Monkeypox (Mpox) is a virulent, smallpox-like disease re-emerging globally. Understanding its genomic diversity and evolution is crucial for developing diagnostics, vaccines, and treatments to combat this public health threat.
Area of Science:
- Virology
- Genomics
- Epidemiology
Background:
- Monkeypox (Mpox) is a zoonotic viral disease, historically endemic to Central and West Africa.
- It presents as a smallpox-like illness and has re-emerged as a significant global health concern.
- The virus remains the most virulent poxvirus since smallpox eradication.
Purpose of the Study:
- To provide a comprehensive overview of the genomic diversity and evolution of the re-emerging Monkeypox virus.
- To highlight the importance of genetic profiling for developing targeted therapeutic strategies.
- To underscore the global health security implications of Mpox outbreaks.
Main Methods:
- This review synthesizes current knowledge on Mpox genomics and evolution.
- It analyzes available data on viral genetic profiles, mutations, and phylogenetic relationships.
- The study emphasizes the need for enhanced global surveillance and case identification.
Main Results:
- Mpox exhibits significant genomic diversity and evolutionary patterns.
- Genetic insights can inform the development of novel therapeutic interventions.
- The spread of Mpox outside endemic regions signifies its global threat potential.
Conclusions:
- A thorough understanding of Mpox genomic diversity and evolution is critical for public health.
- Coordinated efforts among scientists and healthcare professionals are needed for effective control strategies.
- Continued monitoring and research are essential to manage the evolving epidemiology of Mpox.
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