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β-Cyclodextrin-Encapsulated Rhodamine Derivatives Core-Shell Microspheres-Based Fluorescent Sensor for Au³⁺ and

Maniyazagan Munisamy^1,2, Balamurugan Rathinam³, Esakkimuthu Shanmugasundaram¹

¹Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi 630003, India.

|July 29, 2023

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We created fluorescent microspheres using beta-cyclodextrin-encapsulated rhodamine derivatives (β-CD@RH). These microspheres enable bright, stable detection of gold ions (Au3+) in aqueous solutions and living cells.

Area of Science:

Materials Science
Nanotechnology
Analytical Chemistry

Background:

Improving aqueous solubility and biocompatibility of fluorescent probes is crucial for biological applications.
Rhodamine derivatives offer fluorescence but often suffer from poor water solubility.

Purpose of the Study:

To develop novel core-shell microspheres for enhanced fluorescence detection.
To create a simple, green chemistry method for gold microplate synthesis.
To demonstrate the utility of the developed system for fluorescent imaging of Au3+ in living cells.

Main Methods:

Fabrication of beta-cyclodextrin-encapsulated rhodamine derivative core-shell microspheres (β-CD@RH).
Utilizing a one-step, green chemistry strategy for synthesizing gold microplates.

Keywords:

Au3+ detection bioimaging fluorescent core–shell microspheres rhodamine derivative β−cyclodextrin

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Conducting fluorescence assays in aqueous media and live-cell imaging.

Main Results:

β-CD@RH microspheres demonstrated bright and stable fluorescence in the presence of Au3+ ions.
Triangular and hexagonal gold microplates were successfully synthesized.
Effective fluorescent imaging of Au3+ in living cells was achieved.

Conclusions:

β-CD@RH core-shell microspheres are effective fluorescent probes for Au3+ detection.
The developed green chemistry approach provides a facile route to gold microplates.
This system holds potential for sensitive and specific detection of gold ions in biological systems.