[Allergenic action of inactivated influenza vaccines]

The allergenic action of influenza vaccines was evaluated by the determination of the capacity of sera, taken before and after immunization, for inducing the degranulation of rat mast cells in the presence of the vaccine preparation. In this test sera from three groups of volunteers immunized with experimental and commercial batches of influenza inactivated vaccines, purified and concentrated by gradient centrifugation, was studied. The absence of immediate-type allergization after a single administration of the vaccines under study was shown.