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Related Experiment Video

Updated: Jul 20, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Outcome Reporting in Interventional Necrotizing Enterocolitis Studies: A Systematic Review.

Otis C van Varsseveld¹, Daphne H Klerk², Ingo Jester³

¹Department of Surgery, Division of Pediatric Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Journal of Pediatric Surgery

|July 29, 2023

Summary

Necrotizing enterocolitis (NEC) studies show varied outcome reporting, with few focusing on patient life impact. Developing a standardized NEC core outcome set is crucial for consistent and relevant research to improve infant outcomes.

Keywords:

Core outcome set Intervention Necrotizing enterocolitis Outcome reporting Treatment

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Last Updated: Jul 20, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

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Published on: June 8, 2022

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

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Published on: April 10, 2019

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Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

Area of Science:

Neonatal research
Clinical trial methodology
Pediatric surgery

Background:

Increasing incidence of necrotizing enterocolitis (NEC) necessitates improved treatment strategies.
Current NEC treatment research is hampered by inconsistent outcome reporting and limited efficacy studies.
Analysis of outcome reporting in interventional NEC studies is needed.

Purpose of the Study:

To systematically review and analyze outcome reporting in recent interventional studies for necrotizing enterocolitis (NEC).
To identify heterogeneity and gaps in outcome measurement within NEC therapeutic research.

Main Methods:

Systematic review of interventional NEC studies published between January 2016 and June 2023.
Inclusion of clinical trials and change-in-practice cohort studies for NEC patients (Bell's stage ≥ IIa).
Exclusion of diagnostic/preventive studies and non-English publications; outcomes categorized and descriptively analyzed.

Main Results:

Fifteen studies were included, reporting a median of six unique outcomes (range 1-19).
Sixty-six unique outcomes were identified, with 64% reported in only one study.
Mortality was the most frequent outcome (73%), while 'Life impact' outcomes were least common (20% of studies).

Conclusions:

Significant heterogeneity exists in outcome reporting for interventional NEC studies.
There is a notable lack of outcomes related to 'Life impact' in current NEC research.
Establishing a NEC core outcome set is recommended to enhance consistency and patient relevance.