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Nodular Sarcoid Myositis Treated With Hydroxychloroquine Monotherapy.
Oksana V Mayovska1, Elliot D Rosenstein2,3, Neil Kramer2,3
1Internal Medicine, Morristown Medical Center, Morristown, USA.
Cureus
|July 31, 2023
Summary
Sarcoid myositis, a rare muscle inflammation, can be effectively treated with hydroxychloroquine alone. This antimalarial offers a steroid-sparing option for muscular sarcoidosis and other non-acute manifestations.
Area of Science:
- Rheumatology
- Immunology
- Neurology
Background:
- Sarcoidosis is a multisystem inflammatory disease characterized by non-caseating granulomas.
- Skeletal muscle involvement (sarcoid myositis) is uncommon but can be clinically significant.
- Glucocorticoids are standard treatment, but steroid-sparing agents are increasingly used due to side effects.
Observation:
- A case of nodular sarcoid myositis was observed.
- The patient presented with symptoms indicative of muscular sarcoidosis.
Findings:
- Successful treatment of nodular sarcoid myositis was achieved with hydroxychloroquine monotherapy.
- This represents the first reported instance of hydroxychloroquine monotherapy for nodular sarcoid myositis.
Implications:
- Hydroxychloroquine monotherapy may serve as an effective initial treatment for nodular sarcoid myositis.
- This approach could be beneficial for other forms of muscular sarcoidosis.
- Antimalarial monotherapy may be a viable option for non-acute, organ-threatening sarcoidosis manifestations.
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