BRIDGING GAP BETWEEN PRE AND POSTOPERATIVE PROSTATE BIOPSIES: PI RADS CORRELATION WITH FINAL HISTOPATHOLOGICAL DATA

Area of Science:

• Radiology
• Oncology
• Pathology

Background:

• Accurate preoperative grading of prostate cancer is crucial for treatment planning.
• Multiparametric MRI (mpMRI) with PI-RADS scoring is increasingly used for prostate cancer assessment.
• Correlation between MRI findings and histopathology is essential for validating diagnostic accuracy.

Purpose of the Study:

• To correlate Prostate Imaging Reporting and Data System (PI-RADS) scores with Gleason scores (Gs) in prostate cancer.
• To determine the relationship between apparent diffusion coefficient (ADC) values and Gleason scores.
• To assess the compliance of preoperative MRI grading with histopathological findings.

Main Methods:

• Prospective study of 153 treatment-naïve patients with positive prostate cancer biopsies.
• mpMRI interpretation using PI-RADS V.2.1, correlated with histopathological data.
• Pearson's correlation used to analyze PI-RADS and ADC values against Gleason scores.

Main Results:

• A highly positive correlation was found between PI-RADS sum scores and Gleason scores (r=0.646, p=0.000).
• A significant negative correlation was observed between ADC values and Gleason scores (r=-0.849, p=0.000).
• Mean ADC values were calculated for each Gleason grade, showing a clear trend.

Conclusions:

• PI-RADS scores show a strong correlation with Gleason grades in prostate cancer.
• ADC values derived from mpMRI can noninvasively predict Gleason grade preoperatively.
• mpMRI is a valuable tool for preoperative prostate cancer grading, supporting optimal treatment strategies.