Low-cost transition metal catalysed Negishi coupling: an update
Pulluparambil Xavier Thresia Rinu1, Rose Mary Philip1, Gopinathan Anilkumar1
1School of Chemical Sciences, Mahatma Gandhi University, Priyadarsini Hills P O, Kottayam, Kerala, 686560 India. anilgi1@yahoo.com.
Abstract:
The Negishi coupling is a significant C-C bond-forming reaction to access synthetically valuable organic compounds. In recent years, researchers have developed sustainable first-row transition metal (Fe, Co, Ni and Cu) based complexes in place of the conventional Pd catalyst for this reaction. Several such low-cost metal-based catalysts showed high efficiency and potential application in natural product synthesis. This review focuses on the recent achievements in low-cost transition metal-based Negishi coupling reactions, covering reports from 2016.
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