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Related Concept Videos

Chest Physiotherapy01:24

Chest Physiotherapy

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Chest Physiotherapy (CPT) is a therapeutic technique used in respiratory care to improve ventilation, clear bronchial secretions, and enhance the efficiency of respiratory muscles. This therapy includes three primary procedures: postural drainage, percussion, and vibration. It can be performed on spontaneously breathing patients and those who are intubated and mechanically ventilated.
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
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Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

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Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
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Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
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Other Pulmonary Disorders01:17

Other Pulmonary Disorders

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Pneumothorax-II01:27

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Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Senotherapy for lung diseases.

Peter J Barnes1

  • 1National Heart & Lung Institute, Imperial College London, United Kingdom.

Advances in Pharmacology (San Diego, Calif.)
|July 31, 2023
PubMed
Summary
This summary is machine-generated.

Cellular senescence accelerates lung aging in diseases like COPD and IPF. Senotherapies, targeting senescent cells, show promise in treating these conditions and reducing mortality.

Keywords:
Chronic obstructive pulmonary diseaseIdiopathic pulmonary fibrosisMicroRNASenescence-associated secretory phenotypeSenolyticSenostaticSirtuin

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Area of Science:

  • Pulmonology
  • Cellular Biology
  • Gerontology

Background:

  • Chronic lung diseases, including COPD and IPF, exhibit accelerated lung aging.
  • Cellular senescence, characterized by the accumulation of senescent cells, contributes to disease progression.
  • Senescent cells release inflammatory factors (SASP) that exacerbate tissue damage and senescence.

Purpose of the Study:

  • To explore senotherapies as a treatment for chronic lung diseases.
  • To investigate drugs that inhibit senescence (senostatics) or eliminate senescent cells (senolytics).

Main Methods:

  • Review of existing and emerging drugs targeting cellular senescence.
  • Identification of senostatics, including PI3K-mTOR inhibitors, microRNA antagomirs, and antioxidants.
  • Identification of senolytics that induce apoptosis in senescent cells.

Main Results:

  • Senotherapeutics offer a potential strategy to treat the underlying mechanisms of COPD and IPF.
  • Senostatics can inhibit senescence development driven by oxidative stress.
  • Senolytics can selectively eliminate senescent cells.

Conclusions:

  • Targeting cellular senescence holds promise for reducing disease progression and mortality in chronic lung diseases.
  • Clinical trials investigating senotherapies in chronic lung diseases are ongoing.