Activity standardization of ^99mTc by digitizer-based 4πce(LS)-γ and 4πce(PC)-γ coincidence counting

Area of Science:

• Nuclear physics and radiochemistry
• Metrology and measurement science

Background:

• Accurate standardization of radioactive isotopes is crucial for nuclear medicine and research.
• Technetium-99m (99mTc) is a widely used medical radioisotope requiring precise activity concentration determination.

Purpose of the Study:

• To standardize an aqueous solution of 99mTc using sophisticated coincidence counting techniques.
• To validate the obtained activity concentration through an international comparison.

Main Methods:

• Utilized 4πce(LS)-γ and 4πce(PC)-γ coincidence counting setups.
• Employed fast digitizers for data acquisition and list mode recording.
• Applied efficiency extrapolation with four variation techniques for activity concentration determination.
• Performed offline analysis of coincidence relationships.

Main Results:

• Successfully standardized the 99mTc aqueous solution.
• Achieved accurate activity concentration determination through validated methods.
• The standardized value was suitable for international comparison.

Conclusions:

• The employed coincidence counting methods provide accurate standardization of 99mTc.
• The results align with international standards, confirming measurement reliability.
• This work contributes to the metrology of radionuclides for medical applications.