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Energy metabolism: A critical target of cardiovascular injury

Qiyang Li1, Shangzu Zhang1, Gengqiang Yang1

  • 1Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 6, 2023
PubMed

Insights

Abnormal energy metabolism is central to cardiovascular diseases. Understanding cardiac energy metabolism and developing targeted drugs are crucial for effective treatment and prevention strategies.

Area of Science:

  • Cardiology
  • Metabolic Research
  • Pharmacology

Background:

  • Cardiovascular diseases represent a leading global health threat.
  • Aberrant energy metabolism is implicated in the pathogenesis of acute and chronic cardiovascular conditions.
  • Targeting cardiac energy metabolism is an emerging therapeutic strategy.

Purpose of the Study:

  • To review the role of energy metabolism in cardiovascular pathophysiology.
  • To explore potential drug targets for modulating cardiac energy metabolism.
  • To provide insights for clinical cardiovascular disease management.

Main Methods:

  • Literature review of studies on cardiac energy metabolism.
  • Analysis of mechanisms linking energy metabolism to cardiovascular disease.
  • Identification of therapeutic strategies targeting metabolic pathways.

Main Results:

  • Energy metabolism significantly influences cardiovascular disease development.
  • Specific metabolic substrates and pathways are critical in cardiovascular health.
  • Several drug targets for metabolic intervention in cardiovascular disease have been identified.

Conclusions:

  • A deeper understanding of cardiac energy metabolism is needed.
  • Developing drugs that modulate energy metabolism holds promise for cardiovascular treatment.
  • Metabolic interventions could significantly improve cardiovascular disease prevention and therapy.

Keywords:
Diabetic cardiomyopathyEnergy metabolismHeart failureIschemia/reperfusion injuryIschemic heart diseaseMitochondrion

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