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Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
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Effective VTE prophylaxis with enoxaparin after elective THR or TKR: a retrospective observational study
Diogo Nóbrega Catelas1,2, Filipa Cordeiro1,2, Luís Loureiro3
1Department of Orthopedic Surgery, Centro Hospitalar Universitário de Santo António, Porto, Portugal.
Porto Biomedical Journal
|August 7, 2023
Summary
Orthopedic patients undergoing hip or knee replacement (THR/TKR) showed low venous thromboembolism (VTE) rates with enoxaparin prophylaxis. High compliance with VTE prophylaxis led to minimal VTE events in this study.
Area of Science:
- Orthopedics
- Cardiology
- Pharmacology
Background:
- Orthopedic patients face the highest risk of venous thromboembolism (VTE).
- Routine VTE prophylaxis significantly reduces fatal pulmonary embolism (PE) and symptomatic VTE rates after total hip replacement (THR) and total knee replacement (TKR).
- Pre-prophylaxis VTE rates in THR/TKR patients were as high as 50%-70%.
Purpose of the Study:
- To evaluate the effectiveness of VTE prophylaxis in patients undergoing THR and TKR.
- To assess the incidence of VTE in patients treated with enoxaparin post-THR/TKR.
- To analyze VTE prophylaxis practices at Centro Hospitalar Universitário de Santo António (CHUdSA).
Main Methods:
- A retrospective study of 483 patients undergoing elective THR or TKR from March 2019 to February 2020.
- Enoxaparin was used as the VTE prophylaxis drug for all included patients.
- Data on prescribed enoxaparin duration were collected from the nationwide electronic drug prescription system (PEM).
Main Results:
- The study included 192 THR patients (39.75%) and 291 TKR patients (60.25%).
- Enoxaparin was prescribed for an average of 31.86 days for THR and 30.28 days for TKR.
- The incidence of VTE was 3.13% in the THR group and 0.69% in the TKR group.
Conclusions:
- Enoxaparin 40 mg once daily for up to 35 days is the standard VTE prophylaxis for THR/TKR at CHUdSA.
- High therapeutic compliance rates contributed to a low incidence of VTE events.
- The implemented VTE prophylaxis strategy proved effective in minimizing VTE occurrence post-orthopedic surgery.
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