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Published on: May 21, 2019
Cascade Cyclizations Triggered by Photochemically Generated Carbamoyl Radicals Derived from Alkyl Amines
Ganesh Chandra Upreti1, Tavinder Singh1, Divakar Chaudhary1
1Department of Chemistry, IIT Kanpur, Kanpur, 208016 Uttar Pradesh, India.
Abstract:
We report on a visible light-mediated cascade carbamoylation/cyclization of acrylamides using dihydropyridyl carbamoyl donors derived from alkyl amines. Diversely selected acrylamides including 2-cyano-N-arylacrylamides, indolyl- and benzimidazolyl acrylamides, and 2-alkynyl-N-aryl acrylamides participate in this reaction, providing products in good yields. The highlights of this photochemical method include the application of alkyl amine-derived carbamoyl donors, peroxide-free reaction conditions, and a broad scope.
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