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[Antineoplastic action of retinol and its derivatives (retinoids)]
Abstract:
Morphologic alterations in epithelium, caused by imcompetency of retinoids in a diet, were similar to those, obtained after treatment with chemical carcinogens. This suggests to use various derivatives of nature retinoids for treatment of epithelial tumors in skin and other tissues. Cultures of mouse prostatic gland and skin epithelium from metatarsus of chicken embryo were used for study of antitumoral activity of various synthetic retinoids. The most active preparations proved to be cyclopentenyl- and trimethyl methoxyphenyl ethyl ester derivatives of retinolic acid. The antitumoral effect of retinolic acid and its derivatives appears to involve a tight binding of the preparations with specific protein and inhibition of ornithine decarboxylase in tumor. The enzyme is well known to be related to synthesis of DNA, RNA and protein.
Insights
Synthetic retinoids show promise in treating epithelial tumors. Specific retinolic acid derivatives effectively inhibited tumor growth by targeting key cellular processes.
Area of Science:
- Oncology
- Dermatology
- Biochemistry
Background:
- Dietary retinoid deficiency causes epithelial changes similar to carcinogen exposure.
- Retinoids are natural compounds with potential therapeutic applications for epithelial tumors.
Purpose of the Study:
- To investigate the antitumoral activity of synthetic retinoids.
- To identify effective retinoid derivatives for treating epithelial cancers.
Main Methods:
- Cultured mouse prostatic gland epithelium.
- Cultured chicken embryo skin epithelium.
- Assay of antitumoral activity of synthetic retinoids.
Main Results:
- Cyclopentenyl and trimethyl methoxyphenyl ethyl ester derivatives of retinolic acid demonstrated significant antitumoral effects.
- These retinoids bind to specific proteins and inhibit ornithine decarboxylase.
- Inhibition of ornithine decarboxylase impacts DNA, RNA, and protein synthesis.
Conclusions:
- Synthetic retinoids, particularly specific retinolic acid derivatives, are effective against epithelial tumors.
- The mechanism involves protein binding and inhibition of ornithine decarboxylase.
- These findings support the use of retinoids in cancer therapy for skin and other epithelial tissues.