Related Experiment Video
Updated: Jul 19, 2025
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Salvage Therapies for Radiorecurrent Prostate Cancer
Kamran Zargar-Shoshtari1, Pranav Sharma1, Julio Pow-Sang1
1Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, Florida.
Introduction:
We report available salvage options in patients with biochemical recurrence after radiation therapy for prostate cancer.
Methods:
We performed MEDLINE® searches for various salvage options and reviewed the most recent publications on each modality.
Results:
Salvage radical prostatectomy, brachytherapy, cryotherapy and high intensity focused ultrasound are the main therapeutic options available for men with biochemical recurrence after radiation therapy. These modalities have different side effect profiles. There is also wide variability in followup and reporting of oncologic outcomes. Androgen deprivation therapy remains the most common form of therapy after biochemical recurrence.
Conclusions:
No standard salvage therapy exists. Treatments are best administered at specialist centers where there is expertise with managing potential complications.
Related Concept Videos
02:49Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...