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Mepolizumab in allergic bronchopulmonary aspergillosis complicated by infection
Toru Hamada1, Tomoya Katsuta1, Kento Aibara1
1Respiratory Medicine, Ehime Prefectural Central Hospital, Matsuyama, Ehime, 790-0024, Japan.
Abstract:
Allergic bronchopulmonary aspergillosis (ABPA) is an allergic reaction caused by the fungus Aspergillus, and it is often treated with steroids or antifungal agents. However, long-term use of these medications can lead to infections and drug interactions. We present the case of a 71-year-old woman with ABPA who was diagnosed with hepatitis B and active hepatitis C, and sputum analysis revealed the presence of bacteria. Oral steroids were initially administered, but the patient was switched to mepolizumab because of numerous infectious complications. The early introduction of mepolizumab is effective in patients with ABPA complicated by infectious diseases.
Insights
Allergic bronchopulmonary aspergillosis (ABPA) treatment with steroids can cause infections. Mepolizumab offers an effective alternative for ABPA patients experiencing infectious complications, demonstrating early introduction benefits.
Area of Science:
- Pulmonology
- Allergology
- Infectious Diseases
Background:
- Allergic bronchopulmonary aspergillosis (ABPA) is an allergic reaction to Aspergillus.
- Current treatments like steroids and antifungals have risks, including infections and drug interactions.
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