Related Experiment Video
Updated: Jul 19, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Clostridioides difficile Infection in Children: Recent Updates on Epidemiology, Diagnosis, Therapy
Debbie-Ann Shirley1, William Tornel1, Cirle A Warren2,3
1Pediatric Infectious Diseases, Department of Pediatrics.
Clostridioides difficile infection (CDI) is rising in children, often community-associated. New treatments show promise, but optimizing therapy for severe or recurrent pediatric CDI remains critical.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Gastroenterology
Background:
- Clostridioides difficile infection (CDI) is a significant cause of antibiotic-associated diarrhea globally and a leading healthcare-associated infection in the US.
- Pediatric CDI incidence is increasing, with 20,000 annual cases, often community-associated, impacting education and economy.
- Disease severity in children varies widely, from asymptomatic carriage to severe, potentially fatal outcomes, with diagnosis complicated by colonization challenges.
Conclusions:
- While new therapies offer hope, optimizing treatment for severe and recurrent pediatric CDI is an ongoing challenge.
- Accurate diagnostic tools are crucial for effective management of CDI in children.
- Further research is needed to refine therapeutic strategies for pediatric Clostridioides difficile infection.
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06:51Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
09:12A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
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