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Correlations between D-Dimer, C-Reactive Protein and Hematologic Data in Outpatients with COVID-19

Hamide Shllaku-Sefa, Gentian Kasmi, Irena Kasmi

    Clinical Laboratory
    |August 10, 2023
    PubMed

    Insights

    Correlations between D-dimer, C-reactive protein (CRP), and hematologic markers like neutrophil-to-lymphocyte ratio (NLR) are present in COVID-19 outpatients. These markers can help assess disease severity and prognosis in non-hospitalized patients.

    Area of Science:

    • Clinical Medicine
    • Infectious Diseases
    • Hematology

    Background:

    • COVID-19 significantly impacts various patient populations, including outpatients.
    • Understanding inflammatory and hematologic markers is crucial for managing COVID-19.
    • Previous studies focused on hospitalized patients; outpatient data is less explored.

    Purpose of the Study:

    • To evaluate correlations between D-dimer, C-reactive protein (CRP), and hematologic data in outpatients with COVID-19.
    • To determine if correlations observed in hospitalized COVID-19 patients are applicable to outpatients.
    • To identify potential markers for assessing COVID-19 severity and prognosis in the outpatient setting.

    Main Methods:

    • Retrospective study of 100 COVID-19 outpatients (August 2020 - January 2022).
    • Data collected included D-dimer, CRP, and various hematologic parameters (WBC, NLR, lymphocyte count, platelets).
    • Statistical analysis to identify correlations between D-dimer, CRP, and hematologic markers.

    Main Results:

    • Most outpatients were under 60 years old.
    • Elevated CRP (42%) and increased Neutrophil-to-Lymphocyte Ratio (NLR) (23%) were observed in a subset of patients.
    • Significant correlations were found between CRP and D-dimer (r=0.39), CRP and WBC (r=0.42), CRP and NLR (r=0.73), WBC and NLR (r=0.58), and WBC and platelets (r=0.45).

    Conclusions:

    • Correlations between D-dimer, CRP, and hematologic markers exist in COVID-19 outpatients.
    • These markers can be valuable for deciding on further diagnostic tests for severe cases.
    • The findings suggest these markers aid in predicting COVID-19 prognosis for outpatients.
    Abstract

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