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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Protein Networks02:26

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Protein Organization01:24

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Related Experiment Video

Updated: Jul 19, 2025

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

96

MineProt: a stand-alone server for structural proteome curation.

Yunchi Zhu1,2, Chengda Tong2, Zuohan Zhao2

  • 1State Key Laboratory of Digital Medical Engineering, Southeast University, Sipailou No. 2, Nanjing, Jiangsu 210096, China.

Database : the Journal of Biological Databases and Curation
|August 10, 2023
PubMed
Summary
This summary is machine-generated.

MineProt offers a user-friendly solution for curating large-scale proteome structural data generated by AlphaFold-like systems. This open-source tool enhances researcher productivity and facilitates data sharing in structural proteomics.

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • High-throughput proteome structuring technologies, such as AlphaFold, are generating vast amounts of protein structure data.
  • Efficient curation and analysis of this large-scale data are crucial for advancing structural proteomics research.

Purpose of the Study:

  • To introduce MineProt, an open-source software solution for custom curation of high-throughput proteome structure data.
  • To provide researchers with a user-friendly platform for annotating, curating, and analyzing protein structures.

Main Methods:

  • MineProt enables users to set up their own servers with minimal effort.
  • It includes pre-configured scripts for protein annotation and curation.
  • The platform offers a graphical user interface for data analysis and supports plugin-based extensibility.

Main Results:

  • MineProt facilitates the custom curation of novel, high-throughput proteome structure data.
  • The software streamlines the analysis and management of protein structure datasets.
  • It empowers researchers to build personalized servers for their specific needs.

Conclusions:

  • MineProt is expected to significantly boost researcher productivity in structural proteomics.
  • The tool is designed to facilitate seamless data sharing within the research community.
  • MineProt supports researchers in navigating the challenges of large-scale structural data analysis.