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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

291
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
291
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

152
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
152
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
355
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

215
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
215
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

485
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
485
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

170
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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Inflammatory Bowel Diseases: An Updated Overview on the Heat Shock Protein Involvement.

Federica Scalia1,2, Francesco Carini1,3, Sabrina David4

  • 1Biomedicine, Neurosciences and Advanced Diagnostics BIND, School of Medicine, University of Palermo, 90133 Palermo, Italy.

International Journal of Molecular Sciences
|August 12, 2023
PubMed
Summary

Heat shock proteins (HSPs) play a dual role in inflammatory bowel diseases (IBD), influencing disease progression and potentially protecting against colorectal cancer. Further research into HSPs and the chaperone system could lead to new IBD diagnostics and therapies.

Keywords:
Crohn’s diseaseHSPsIBDimmunemolecular chaperonesulcerative colitis

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Area of Science:

  • Gastroenterology
  • Immunology
  • Molecular Biology

Background:

  • Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), involve aberrant immune interactions between the intestinal epithelium and microbiota.
  • Heat shock proteins (HSPs) are increasingly recognized for their role in IBD pathogenesis.

Purpose of the Study:

  • To review the genetic, epigenetic, immune, and molecular roles of HSPs in IBD.
  • To highlight the potential diagnostic, prognostic, and therapeutic value of HSPs and the chaperone system (CS) in IBD management.

Main Methods:

  • Literature review of recent studies on HSPs in IBD.
  • Analysis of HSP expression in intestinal tissues and sera of IBD patients.
  • Discussion of HSPs' dual role in inflammation, fibrosis, and cancer prevention.

Main Results:

  • HSPs are differentially expressed in CD and UC patients.
  • HSPs can promote inflammation and fibrosis but also offer protection against complications like colorectal cancer.
  • HSPs mediate interactions between the intestinal microbiota and epithelial cells.

Conclusions:

  • HSPs have a complex, stage-dependent role in IBD.
  • The molecular chaperone system, including HSPs, holds significant potential for IBD diagnostics, prognostics, and therapeutics.
  • Further exploration of HSPs could lead to novel drugs with improved side-effect profiles for IBD treatment.