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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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A New Treatment Strategy that Reduces Growth/Differentiation Factor-15 in Type-2 Diabetes Mellitus: Major

Hasan E Yücel, Bilal İlanbey

    Alternative Therapies in Health and Medicine
    |August 13, 2023
    PubMed
    Abstract

    Insights

    Major autohemotherapy significantly reduced Growth/differentiation factor-15 (GDF-15) levels in patients with type-2 diabetes mellitus. This complementary therapy shows promise in managing GDF-15, a marker of inflammation and cardiovascular risk.

    Area of Science:

    • Endocrinology and Metabolism
    • Cardiovascular Medicine
    • Nephrology

    Background:

    • Growth/differentiation factor-15 (GDF-15) is a key biomarker for inflammation, renal damage, and cardiovascular risk in type-2 diabetes mellitus.
    • Elevated GDF-15 levels are associated with adverse outcomes in diabetic patients.
    • Researchers are exploring novel therapeutic strategies to reduce GDF-15 levels.

    Purpose of the Study:

    • To investigate the impact of major autohemotherapy on GDF-15 levels in patients with type-2 diabetes mellitus.
    • To evaluate major autohemotherapy as a potential complementary treatment for type-2 diabetes mellitus.

    Main Methods:

    • A prospective laboratory study was conducted with 21 patients with type-2 diabetes mellitus and 14 healthy volunteers.
    • Participants received 10 sessions of major autohemotherapy (ozone gas infusion) twice weekly.
    • GDF-15, fasting glucose, HbA1c, and lipid profiles were measured before and after treatment.

    Main Results:

    • Type-2 diabetes mellitus patients exhibited higher baseline levels of GDF-15, glucose, HbA1c, and triglycerides, and lower HDL cholesterol compared to healthy controls.
    • Major autohemotherapy led to a significant reduction in GDF-15 and LDL cholesterol in the type-2 diabetes mellitus group.
    • No significant changes in measured parameters were observed in the healthy volunteer group.

    Conclusions:

    • Major autohemotherapy effectively reduces GDF-15 levels in patients with type-2 diabetes mellitus.
    • This therapy may offer a new strategy to mitigate inflammation and cardiovascular risk associated with type-2 diabetes.
    • Major autohemotherapy contributes to the therapeutic benefits of ozone therapy in managing type-2 diabetes mellitus.

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