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mTOR pathway - a potential therapeutic target in stroke.

Konstantinos Melanis^1,2, Maria-Ioanna Stefanou³, Konstantinos M Themistoklis^2,4

¹Second Department of Neurology, School of Medicine and 'Attikon' University Hospital, National and Kapodistrian University of Athens, Rimini 1 Chaidari, Athens 12462, Greece.

Therapeutic Advances in Neurological Disorders

|August 14, 2023

Summary

The mammalian target of rapamycin (mTOR) pathway influences inflammation and autophagy after stroke. Modulating mTOR offers potential neuroprotection and new therapeutic strategies for stroke patients.

Keywords:

mTOR pathway neuroprotection stroke tuberous sclerosis complex

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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

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Area of Science:

Neuroscience
Molecular Biology
Pathophysiology

Background:

Stroke is a leading cause of death and disability globally.
The mammalian target of rapamycin (mTOR) pathway regulates critical cellular processes.
mTOR signaling is implicated in the brain's response to ischemic injury.

Purpose of the Study:

To review the role of the mTOR pathway in acute ischemic stroke.
To identify neuroprotective agents targeting the mTOR pathway.
To discuss the therapeutic potential of mTOR modulation in stroke.

Main Methods:

Literature review of studies on mTOR signaling in stroke.
Analysis of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) roles.
Examination of downstream signaling pathways including inflammation and autophagy.

Main Results:

The mTOR pathway significantly impacts post-ischemic inflammation and autophagy.
Modulation of mTOR can determine neuronal apoptosis or survival.
Hamartin is highlighted as a potential neuroprotective agent targeting mTOR.

Conclusions:

The mTOR pathway is a critical regulator in ischemic stroke pathophysiology.
Targeting mTOR offers promising neuroprotective strategies.
Further research is needed to elucidate specific molecules and pathway steps for clinical application.