[Enhancement of the antineoplastic effect of local hyperthermia by induced hyperglycemia]

It is shown that the antitumour effect of local hyperthermia (2450 MHz, 43 degrees C, 60 min) is enhanced essentially if it follows immediately after i. v. infusion of 20% glucose solution at a rate of 80 mg X kg-1 X min-1 for 90 min in experiments on rats bearing the Guerin carcinoma. Under such a combined treatment the rate of tumour growth decreases by a factor of 2. An assumption is advanced that such an enhancement of the hyperthermia effect is caused mainly by low pH values of the tumour which are observed under hyperglycemia.