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Published on: May 21, 2019
Photoredox Catalysis with Visible Light for Synthesis of Thioxanthones Derivatives
Wen Liao1, Jing Hou2, Hongding Tang2
1Department of Polymer Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, P. R. China.
Abstract:
A visible-light-promoted and transition-metal-free photoredox-catalysis strategy is developed for the synthesis of thioxanthone derivatives (TXs). The mechanistic study and density functional theory calculations suggest that visible-light-promoted intramolecular cyclization can be divided into hydrogen atom transfer, C-C formation, and oxidative dehydrogenation with high regioselectivity and reactivity. Significantly, this C-C formation strategy can be used in TXs-based commercial photoinitiators and drugs at the gram level.
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