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Updated: Jul 19, 2025
08:29
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
Published on: May 14, 2018
10.0K
Paclitaxel-induced dorsal hand-foot syndrome
Eugenie Y Quan1, Casey Engel, Patrick S Rush
1Section of Dermatology, Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, VA. quaney@vcu.edu.
Dermatology Online Journal
|August 17, 2023
Summary
Hand-foot syndrome (HFS) is a chemotherapy side effect. This case highlights paclitaxel causing HFS on the dorsal hands, emphasizing early detection for continued cancer treatment and patient well-being.
Area of Science:
- Oncology
- Dermatology
Background:
- Hand-foot syndrome (HFS), or palmoplantar erythrodysesthesia, is a common adverse effect of chemotherapy.
- It typically manifests as skin changes on the palms and soles.
Observation:
- Paclitaxel, a chemotherapy agent, uncommonly causes HFS.
- This report details an unusual case of HFS specifically on the dorsal hands.
Findings:
- A 66-year-old male with metastatic angiosarcoma developed HFS on his dorsal hands due to paclitaxel treatment.
- The presentation differed from typical HFS, being localized dorsally rather than palmarly.
Implications:
- Early recognition of atypical HFS presentations is crucial for managing chemotherapy side effects.
- Prompt HFS management enables uninterrupted chemotherapy, improving patient quality of life during cancer treatment.
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