Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Suppression of the myofibroblastic cancer-associated fibroblast phenotype to enhance anti-PD-1 response.

Journal of experimental & clinical cancer research : CR·2026

Same author

The <i>DNAJB1-PRKACA</i> Oncogenic Fusion Drives Stepwise Biliary and Pancreatic Carcinogenesis from Intraductal Precursor Lesions.

bioRxiv : the preprint server for biology·2026

Same author

Dopamine drives persistent remodelling of the maternal brain.

Nature·2026

Same author

The Role of the Obturator Nerve-Acute Nerve Grafting After Resection of a Plexiform Obturator Nerve Schwannoma: A Case Report.

JBJS case connector·2026

Same author

Evaluating the Clinical Relevance of Elevated Mucosal Mast Cells in the Gastrointestinal Tract.

Journal of clinical gastroenterology·2025

Same author

Endoscopic Ultrasound With Fine-Needle Biopsy for Rare Pancreatic Metastasis: A Case Series of Neuroendocrine Transformation From Primary Prostate Cancer.

ACG case reports journal·2025

Search research articles

Related Experiment Video

Updated: Jun 14, 2025

Bioluminescent Orthotopic Model of Pancreatic Cancer Progression

Bioluminescent Orthotopic Model of Pancreatic Cancer Progression

Published on: June 28, 2013

Pathologic Features of Primary Pancreatic Malignancies.

Tarek Abi-Saab¹, Ashley M Cunningham², Patrick S Rush^3,4

¹School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.

Cancer Treatment and Research

|August 30, 2024

Summary

This chapter reviews pancreatic lesion pathology, focusing on evolving classifications for cystic lesions and neuroendocrine tumors. Accurate pathologic evaluation is crucial for physicians managing gastrointestinal malignancies.

More Related Videos

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

Related Experiment Videos

Last Updated: Jun 14, 2025

Bioluminescent Orthotopic Model of Pancreatic Cancer Progression

Bioluminescent Orthotopic Model of Pancreatic Cancer Progression

Published on: June 28, 2013

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

Area of Science:

Gastroenterology and Hepatology
Surgical Pathology
Oncology

Background:

Pancreatic lesions encompass a spectrum of benign and malignant conditions.
Accurate pathologic classification is essential for patient management and treatment strategies.
Evolving classifications, especially for cystic lesions and neuroendocrine tumors, necessitate updated physician understanding.

Purpose of the Study:

To explore the pathologic features of benign and malignant pancreatic lesions.
To highlight the importance of current pathologic classifications in clinical practice.
To emphasize the need for physicians to stay abreast of evolving diagnostic criteria.

Main Methods:

Review of current literature and pathologic classification systems for pancreatic lesions.
Discussion of key diagnostic features differentiating benign from malignant entities.
Emphasis on updated criteria for cystic neoplasms and neuroendocrine tumors.

Main Results:

Detailed description of the histopathologic characteristics of various pancreatic lesions.
Identification of critical features influencing diagnosis and prognosis.
Illustrative examples of challenging cases and their classification.

Conclusions:

Pathologic classification of pancreatic lesions is dynamic and requires continuous learning.
Physicians treating gastrointestinal malignancies must be proficient in interpreting pancreatic pathology.
Adherence to updated classifications improves diagnostic accuracy and patient outcomes.