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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Metabolic Reprogramming in Cancer Stem Cells.

Gaurav Ranjan1, Srijani Dasgupta2, Uttam Kumar Mishra3

  • 1Department of Pharmacy, School of Health Science, Central University of South Bihar, Gaya, Bihar, India.

Cancer Treatment and Research
|May 17, 2026
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) survive and resist therapy by adapting their metabolism. Targeting CSC metabolism offers a promising strategy for effective cancer treatments.

Keywords:
Cancer stem cellsGlycolysisMetabolic reprogrammingMetabolic targetingReverse Warburg effectTumor microenvironment

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Area of Science:

  • Cancer Biology
  • Metabolic Pathways
  • Tumor Microenvironment

Background:

  • Cancer stem cells (CSCs) possess self-renewal and differentiation capabilities, contributing to therapy resistance and relapse.
  • CSCs exhibit metabolic flexibility, adapting energy production (glycolysis, oxidative phosphorylation) and biosynthesis (lipids, amino acids) to survive stress and low oxygen.
  • The tumor microenvironment (TME) influences CSC metabolism through cellular crosstalk and metabolic interplay, such as the reverse Warburg effect.

Purpose of the Study:

  • To explore the metabolic adaptability of cancer stem cells (CSCs).
  • To understand how metabolic reprogramming contributes to CSC survival, tumor progression, and therapy resistance.
  • To identify metabolic vulnerabilities of CSCs for novel therapeutic strategies.

Main Methods:

  • Analysis of metabolic pathways utilized by CSCs, including glycolysis, oxidative phosphorylation (OXPHOS), and fatty acid oxidation.
  • Investigation of the role of amino acid metabolism (glutamine, serine, glycine) in CSC survival and biosynthesis.
  • Examination of the influence of the tumor microenvironment (TME) on CSC metabolic reprogramming.

Main Results:

  • CSCs dynamically switch between glycolysis and OXPHOS depending on the biological context.
  • Lipid and amino acid metabolism are crucial for CSC energy production, biosynthesis, redox homeostasis, and epigenetic regulation.
  • Metabolic interplay within the TME, like the reverse Warburg effect, supports CSC survival and therapy resistance.

Conclusions:

  • Metabolic reprogramming is fundamental to CSC survival, therapy resistance, and tumor progression.
  • Targeting CSC metabolism using glycolytic, mitochondrial, lipid, or amino acid inhibitors can enhance tumor sensitivity to conventional therapies.
  • Combinatorial therapies targeting CSC metabolism show promise for achieving durable and effective cancer treatment outcomes.