Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Statistical insights into premenstrual syndrome and dysphoric disorder: understanding menstrual health challenges in pre-university students.

International journal of adolescent medicine and health·2026
Same author

The Index for Preventive and Interceptive Orthodontic Treatment Needs (IPION): a scoping review.

The Saudi dental journal·2026
Same author

Locoregional Recurrence-Free Survival in Postmastectomy Breast Cancer: A Comparative Longitudinal Study of Hypofractionated Versus Conventional Fractionated Radiation Therapy.

Indian journal of surgical oncology·2025
Same author

Advances in Lipid-Based Nanomedicine: Pathway Specific siRNA Therapy and Optimizing Delivery for Hepatocellular Carcinoma.

International journal of nanomedicine·2025
Same author

A critical review of the synergistic potential of targeting p53 and CAR T cell therapy in cancer treatment.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Clinical and biochemical amenorrhea in premenopausal patients with breast cancer treated with chemotherapy - a prospective cohort study.

BMC cancer·2025

Related Experiment Video

Updated: May 19, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Clinical Trials and Translational Advances in Metabolic Targeting.

Hariharan Thirumalai Vengateswaran1, Mohammad Habeeb1, Huay Woon You2

  • 1Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, India.

Cancer Treatment and Research
|May 17, 2026
PubMed
Summary

Metabolic reprogramming offers new therapeutic strategies for diseases. Advanced analysis and AI integration are key to overcoming challenges and personalizing treatments for better patient outcomes.

Keywords:
Artificial intelligenceCancerClinical trialsMetabolomics

More Related Videos

Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening
06:50

Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening

Published on: September 5, 2025

Related Experiment Videos

Last Updated: May 19, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening
06:50

Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening

Published on: September 5, 2025

Area of Science:

  • Biomedical research
  • Metabolic pathways
  • Disease therapeutics

Background:

  • Metabolic reprogramming is a hallmark of various disorders.
  • Metabolic therapies show promise but face challenges due to complex cellular networks.
  • Variability and resistance hinder the advancement of metabolic treatments.

Purpose of the Study:

  • To provide a comprehensive overview of clinical trials and advancements in metabolic targeting.
  • To highlight the role of small-molecule inhibitors and multi-omics technologies.
  • To discuss the integration of AI and machine learning in metabolic therapies.

Main Methods:

  • Review of recent clinical trials and translational advancements.
  • Focus on small-molecule inhibitors and multi-omics technologies.
  • Integration of artificial intelligence (AI) and machine learning (ML) for personalized medicine.

Main Results:

  • Metabolism-based treatments offer potential for individualized and accurate therapies.
  • Advanced single-cell analysis methods are crucial for overcoming variability and resistance.
  • AI/ML, metabolomics, and advanced imaging enable patient stratification and treatment optimization.

Conclusions:

  • Metabolic targeting is transforming biomedical treatment, offering novel disease management opportunities.
  • Personalized metabolic therapies are becoming feasible through advanced analytical methods and AI.
  • Continued research in metabolic pathways promises more effective and targeted disease interventions.