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Updated: Jul 19, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Injectable hydrogel particles for amorphous solid formulation of biologics.

Amir Erfani¹, Paul Reichert², Chakravarthy N Narasimhan²

¹Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

|August 18, 2023

Summary

This summary is machine-generated.

Scientists developed a novel formulation for stable, high-concentration injectable biologics. This method combines solid stability with liquid benefits, eliminating drying and reconstitution for advanced cancer immunotherapies.

Keywords:

Bioengineering Biomaterials Materials science Polymers

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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

Area of Science:

Biopharmaceutical formulation
Materials science
Cancer immunotherapy

Background:

Advancements in cancer immunotherapy necessitate high-concentration biologic formulations.
Current formulation methods face challenges with stability and injectability at high concentrations.

Purpose of the Study:

To develop a formulation enabling high-concentration, stable, and injectable biologics.
To integrate amorphous solid forms of biologics with hydrogel properties for improved delivery.

Main Methods:

Formulation of biologics as amorphous solids within aqueous suspension.
Integration of amorphous antibody solids with soft alginate hydrogel particles.
Evaluation using anti-PD-1 antibody (pembrolizumab) and human immunoglobulin G.

Main Results:

Achieved stable, high-concentration (up to 300 mg/mL) injectable biologic formulations.
The formulation combines solid-state stability with liquid-like injectability.
Alginate hydrogel matrix facilitated high particle packing and maintained biologic quality.

Conclusions:

The developed formulation technology addresses key challenges in biologic drug delivery.
This platform offers a widely applicable solution for stable, high-concentration injectable biologics.
Eliminates the need for drying and reconstitution, simplifying the process.