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Sleep, Circadian Rhythms, and Cognitive Dysfunction in Huntington's Disease.
Emily S Fitzgerald1, Julie C Stout1, Yifat Glikmann-Johnston1
1School of Psychological Sciences, and Turner Institute for Brain and Mental Health, Monash University, Clayton, VIC, Australia.
Poor sleep and disrupted circadian rhythms are linked to cognitive decline in Huntington's disease (HD). Further research is needed to understand these connections across all disease stages.
Area of Science:
- Neuroscience
- Sleep Medicine
- Genetics
Background:
- Sleep and circadian disruption are known to cause cognitive deficits in healthy individuals.
- Individuals with Huntington's disease (HD) experience compromised brain function and disturbances in sleep and circadian rhythms, potentially heightening cognitive vulnerability.
Conclusions:
- Associations between poor sleep and cognitive dysfunction are evident in manifest HD.
- The relationship between circadian disturbances and cognitive impairment in HD remains undetermined.
- Future research should investigate diverse disease stages, control for external factors, and use targeted cognitive assessments to guide interventions for cognitive symptoms in HD.
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