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Published on: February 2, 2021
Meta-Analysis of Prophylactic Renal Replacement Therapy after Cardiac Catheterization in Patients with Chronic Kidney
Yutthapong Temtanakitpaisan1, Suchaorn Saengnipanthkul2, Wasawat Vutthikraivit3
1Division of Cardiology, Bangkok Hospital Khon Kaen, Bangkok Dusit Medical Services Plc., Khon Kaen, Thailand; Faculty of Medicine, Mahasarakham University, Mahasarakham, Thailand.
Insights
Prophylactic renal replacement therapy after cardiac catheterization may not reduce mortality in chronic kidney disease patients. However, it appears to decrease the need for hemodialysis during hospitalization and long-term renal replacement therapy.
Area of Science:
- Nephrology
- Cardiology
- Critical Care Medicine
Background:
- The efficacy of prophylactic renal replacement therapy (RRT) post-cardiac catheterization for chronic kidney disease (CKD) patients is uncertain.
- Cardiac catheterization poses risks to renal function in CKD patients.
Conclusions:
- Prophylactic RRT does not appear to lower 1-year mortality in CKD patients after coronary angiography.
- Prophylactic RRT may reduce the risk of in-hospital hemodialysis and the need for RRT within one year.
Background:
The benefits of prophylactic renal replacement therapy after cardiac catheterization in patients with chronic kidney disease remain unclear. The aim of this study is to confirm the benefit of prophylactic renal replacement therapy after cardiac catheterization.
Methods:
We systematically searched for studies published from inception to December 2022 examining the benefits of prophylactic renal replacement therapy after cardiac catheterization in MEDLINE and EMBASE. Data analysis was performed according to the PRISMA statement using the Mantel-Haenszel method.
Results:
Five studies met the inclusion criteria, which comprised of 532 chronic kidney disease patients who underwent coronary angiography (268 had prophylactic renal replacement therapy and 264 did not have prophylactic renal replacement therapy). The pooled analysis revealed a non-significant decreased risk of 1-year mortality in chronic kidney disease patients who underwent coronary angiography and prophylactic renal replacement therapy compared to those who did not have prophylactic renal replacement therapy (RR = 0.59; P =.18; CI: 0.28-1.2795, I2 = 60.4%). The risk of hemodialysis during hospitalization and renal replacement therapy requirement in 1 year in chronic kidney disease patients who underwent coronary angiography and prophylactic renal replacement therapy were lower than in those who did not have prophylactic renal replacement therapy (RR = 0.13; P =.001; CI: 0.04-0.43, I2 = 9.1% and RR = 0.29; P =.015; CI: 0.11-0.78, I2 = 49.9%, respectively). The sensitivity analysis demonstrated that the overall findings remained consistent and did not significantly alter.
Conclusions:
Prophylactic renal replacement therapy did not seem to lower 1-year mortality among chronic kidney disease patients who underwent coronary angiography. However, prophylactic renal replacement therapy appeared to reduce the risk of hemodialysis during hospitalization and renal replacement therapy requirement in 1 year.
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