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Development of Optimal Virtual Screening Strategies to Identify Novel Toll-Like Receptor Ligands Using the DockBox
Jordane Preto1, Francesco Gentile2,3
1Centre de Recherche en Cancérologie de Lyon, Université Claude Bernard Lyon 1, Lyon, France. jordane.preto@univ-lyon1.fr.
Abstract:
Toll-like receptors (TLRs) represent attractive targets for developing modulators for the treatment of many pathologies, including inflammation, cancer, and autoimmune diseases. Here, we describe a protocol based on the DockBox package that enables to set up and perform structure-based virtual screening in order to increase the chance of identifying novel TLR ligands from chemical libraries.
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