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PDGF-C promotes cell proliferation partially via downregulating BOP1
Jiahui Li1, Wenjie Hu1, Ruting Zhang1
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Cell Biology International
|August 24, 2023
Summary
Platelet-derived growth factor C (PDGF-C) downregulates block of proliferation 1 (BOP1), a key regulator of cell division. This PDGF-C-BOP1 signaling pathway influences cell proliferation, impacting vascular system functions.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- Platelet-derived growth factor C (PDGF-C) is implicated in vascular system functions and cell proliferation.
- The precise molecular mechanisms underlying PDGF-C's regulation of cell proliferation remain incompletely understood.
Purpose of the Study:
- To investigate the molecular mechanism of PDGF-C in modulating cell proliferation.
- To elucidate the role of block of proliferation 1 (BOP1) in PDGF-C signaling.
Main Methods:
- Screening for factors regulated by PDGF-C.
- Analyzing BOP1 mRNA and protein levels in PDGF-C treated cells and PDGF-C deficient mice.
- Investigating the effects of BOP1 overexpression and knockdown on HEK293A cell proliferation.
Main Results:
- PDGF-C treatment downregulated BOP1 at both mRNA and protein levels.
- BOP1 was upregulated in PDGF-C deficient mice.
- Overexpression of BOP1 inhibited cell proliferation, while BOP1 knockdown promoted it.
- Downregulation of BOP1 attenuated the mitogenic effect of PDGF-C.
Conclusions:
- A novel PDGF-C-BOP1 signaling pathway that modulates cell proliferation has been identified.
- BOP1 acts as a critical mediator in PDGF-C's regulation of cell growth.
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