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Nanoprobe-based molecular imaging for tumor stratification.

Xianbin Ma1, Mingchuan Mao1, Jiaqi He2

  • 1School of Medical Technology, Beijing Institute of Technology, Beijing 100081, P. R. China.

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|August 24, 2023
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Summary

Nanoprobe technology aids in cancer patient stratification by visualizing tumors and releasing factors. This helps distinguish treatment responders from non-responders across various cancer therapies.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Tumor heterogeneity leads to varied patient responses to cancer therapies.
  • Accurate patient stratification is crucial for effective treatment selection.
  • Nanoprobes offer unique properties for visualizing tumors and guiding therapy.

Purpose of the Study:

  • To review nanoprobes for cancer patient stratification.
  • To discuss nanoprobes that visualize biomarkers and release inflammatory factors.
  • To highlight advancements in nanoprobes for diverse therapeutic modalities.

Main Methods:

  • Review of nanoprobes' features and design principles.
  • Analysis of nanoprobes in chemotherapy, radiotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, ferroptosis, and immunotherapy.
  • Discussion of challenges and future perspectives.

Main Results:

  • Nanoprobes can visualize specific cell types and biomarkers.
  • Nanoprobes can release inflammatory factors to modulate tumor microenvironments.
  • Recent advancements show nanoprobes' utility across multiple cancer treatment strategies.

Conclusions:

  • Nanoprobes are promising tools for cancer patient stratification.
  • Further development is needed to overcome challenges in clinical applications.
  • Nanoprobe technology can enhance the efficacy of various cancer therapies.