Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy01:27

Tumor Immunotherapy

524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep learning in tumour genomics: from multi-omics integration to precision oncology.

Open biology·2026
Same author

Tumor-Tropic Bacterial-Nanoparticle Hybrids for Metabolic Reprogramming and Cancer Immunotherapy.

ACS nano·2026
Same author

Biologically Adaptable Quantum Dots: Intracellular in Situ Synthetic Strategy and Mechanism.

Accounts of chemical research·2026
Same author

Effects of deep brain stimulation on non-motor symptoms in Parkinson's disease: insights from longitudinal studies using consistent evaluation scales.

Journal of neurology·2026
Same author

Cumulative social determinants of health and frailty risk in older adults.

BMC geriatrics·2025
Same author

A Spatiotemporal Causal Model for Revealing Developmental Changes in Infants' Brain Effective Connectivity Networks During the First Year of Life.

IEEE transactions on bio-medical engineering·2025

Related Experiment Video

Updated: Jul 3, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.6K

Nano-Engineering Strategies for Tumor-Specific Therapy.

Zijin Li1, Hai-Yan Xie2, Weidong Nie1

  • 1School of Life Science, Beijing Institute of Technology, No. 5, Zhongguancun South Street, Beijing, 100081, China.

Chemmedchem
|February 15, 2024
PubMed
Summary

Smart nanodelivery systems (NDSs) offer improved drug delivery by overcoming limitations like rapid clearance and poor tumor targeting. Engineering NDSs with camouflage, biorecognition, and stimuli-responsiveness enhances therapeutic efficacy and reduces toxicity.

Keywords:
bioinspirednanodelivery systemsstimuli-responsivetumor targeting

More Related Videos

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

6.5K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.7K

Related Experiment Videos

Last Updated: Jul 3, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.6K
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

6.5K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.7K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Nanodelivery systems (NDSs) show potential for enhanced drug efficacy and reduced side effects.
  • Current NDS applications are limited by rapid clearance, non-specific biodistribution, and insufficient tumor accumulation.
  • Engineering modifications are crucial for targeted therapy and minimizing systemic toxicity.

Purpose of the Study:

  • To review principles, methods, and advancements in engineering functional nanodelivery systems.
  • To highlight the development of "smart" NDSs integrating multiple functionalities.
  • To discuss future prospects and challenges in precise nanoengineering for nanodelivery systems.

Main Methods:

  • Systematic review of existing literature on nanodelivery systems.
  • Analysis of engineering strategies for enhanced NDS performance.
  • Discussion of integrated functionalities: camouflage, biorecognition, and stimuli-responsiveness.

Main Results:

  • Functional NDSs can overcome limitations of conventional systems, improving tumor targeting and reducing off-target effects.
  • Integration of camouflage, biorecognition, and stimuli-responsiveness leads to "smart" NDSs with high therapeutic potential.
  • Progress in nanoengineering enables more precise control over NDS behavior in vivo.

Conclusions:

  • Advanced nanodelivery systems hold significant promise for targeted cancer therapy and personalized medicine.
  • Overcoming challenges in nanoengineering is key to realizing the full potential of NDSs.
  • Future research should focus on developing sophisticated NDSs for improved clinical outcomes.