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Circulating Sphingolipids and Glucose Homeostasis: An Update
Sarah Ali-Berrada1,2, Jeanne Guitton3, Sophie Tan-Chen1,2
1Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, F-75006 Paris, France.
International Journal of Molecular Sciences
|August 26, 2023
Summary
Circulating sphingolipids like ceramides and sphingosine-1-phosphate (S1P) are linked to obesity and metabolic disorders. These lipids may act as biomarkers and mediators in glucose metabolism dysregulation.
Area of Science:
- Biochemistry
- Metabolic disease research
- Lipidomics
Background:
- Sphingolipids are key membrane components involved in cellular processes.
- Obesity links sphingolipids to inflammation, apoptosis, and insulin resistance.
- Ceramides and sphingosine-1-phosphate (S1P) are circulating sphingolipids altered in metabolic disorders.
Purpose of the Study:
- To review molecular mechanisms of ceramide and S1P regulation.
- To explore how circulating sphingolipids mediate glucose metabolism changes.
- To highlight sphingolipids as potential biomarkers and mediators in metabolic diseases.
Main Methods:
- Literature review of molecular mechanisms.
- Analysis of sphingolipid association with lipoproteins and extracellular vesicles.
- Discussion of sphingolipid impact on glucose homeostasis.
Main Results:
- Sphingolipids, particularly ceramides and S1P, are implicated in metabolic dysregulation.
- Circulating sphingolipids are associated with lipoproteins and extracellular vesicles.
- These lipids may serve as both predictive biomarkers and active mediators of glucose metabolism alterations.
Conclusions:
- Sphingolipids play a dual role in metabolic diseases as biomarkers and mediators.
- Understanding ceramide and S1P regulation is crucial for metabolic health.
- Targeting sphingolipid pathways could offer therapeutic strategies for glucose metabolism disorders.
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