Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyclometalated palladium complexes as promising antimycoplasmatic drugs.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

NW-based sample preparation for ultrahigh vacuum STM imaging.

Nanotechnology·2025
Same author

Carrier Recombination in Nitride-Based Light-Emitting Devices: Multiphonon Processes, Excited Defects, and Disordered Heterointerfaces.

Nanomaterials (Basel, Switzerland)·2024
Same author

Indirect bandgap MoSe<sub>2</sub> resonators for light-emitting nanophotonics.

Nanoscale horizons·2023
Same author

Features of the Carrier Concentration Determination during Irradiation of Wide-Gap Semiconductors: The Case Study of Silicon Carbide.

Materials (Basel, Switzerland)·2022
Same author

Application of Grazing-Incidence X-ray Methods to Study Terrace-Stepped SiC Surface for Graphene Growth.

Materials (Basel, Switzerland)·2022

Related Experiment Video

Updated: Jul 18, 2025

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.3K

Quality Assessment of Processed Graphene Chips for Biosensor Application.

Natalia M Shmidt1, Evgeniya I Shabunina1, Ekaterina V Gushchina1

  • 1Ioffe Institute, 26 Politekhnicheskaya, 194021 St. Petersburg, Russia.

Materials (Basel, Switzerland)
|August 26, 2023
PubMed
Summary

Photoresist residues on graphene chips significantly impact biosensor reproducibility. Controlling these residues with atomic force microscopy (AFM) and cleaning improves chip resistance and surface roughness for reliable biosensor applications.

Keywords:
graphene chiplow-frequency noisephotoresist residuessurface topography

More Related Videos

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.3K
Manufacturing of a Nafion-coated, Reduced Graphene Oxide/Polyaniline Chemiresistive Sensor to Monitor pH in Real-time During Microbial Fermentation
11:18

Manufacturing of a Nafion-coated, Reduced Graphene Oxide/Polyaniline Chemiresistive Sensor to Monitor pH in Real-time During Microbial Fermentation

Published on: January 7, 2019

8.6K

Related Experiment Videos

Last Updated: Jul 18, 2025

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.3K
Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.3K
Manufacturing of a Nafion-coated, Reduced Graphene Oxide/Polyaniline Chemiresistive Sensor to Monitor pH in Real-time During Microbial Fermentation
11:18

Manufacturing of a Nafion-coated, Reduced Graphene Oxide/Polyaniline Chemiresistive Sensor to Monitor pH in Real-time During Microbial Fermentation

Published on: January 7, 2019

8.6K

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biosensor Technology

Background:

  • Graphene is a promising material for biosensor applications due to its unique electrical properties.
  • The manufacturing process of graphene-based biosensor chips can introduce defects that affect performance.
  • Reproducibility is a critical challenge in the development of reliable graphene biosensors.

Purpose of the Study:

  • To assess the impact of photoresist residues on graphene quality for biosensors.
  • To investigate methods for improving graphene chip quality and reproducibility.
  • To establish correlations between material properties and low-frequency noise characteristics.

Main Methods:

  • Atomic Force Microscopy (AFM) for surface topography and roughness analysis.
  • Raman Spectroscopy for material characterization.
  • Low-frequency noise investigation to assess material defects and stress distribution.
  • Photolithography (PLG) process simulation and residue analysis.

Main Results:

  • Photoresist residues increased chip resistance spread (1-10 kOhm) and RMS roughness (up to 10x).
  • AFM-guided cleaning post-photolithography reduced resistance spread (1-1.6 kOhm) and restored surface roughness.
  • Low-frequency voltage fluctuation spectral density (SU) effectively identified low-quality graphene and inhomogeneous stress.

Conclusions:

  • Controlling photoresist residues is crucial for reproducible graphene biosensor fabrication.
  • AFM and low-frequency noise analysis are effective tools for quality control in graphene chip manufacturing.
  • Optimized cleaning protocols can significantly enhance the performance and reliability of graphene-based biosensors.