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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Improving Riparin-A Dissolution through a Laponite Based Nanohybrid.

Duanne Mendes Gomes1, Lyghia Maria Araújo Meirelles2,3, Paulo Monteiro Araujo1

  • 1Post Program on Pharmaceutical Sciences, Federal University of Piauí-UFPI, Teresina 64049-550, Piauí, Brazil.

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Summary

This study developed a Riparin-A/Laponite nanohybrid system to improve Riparin-A

Keywords:
LaponiteRiparin-Acytotoxicitydissolutionnanohybrid

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Area of Science:

  • Nanotechnology
  • Pharmacology
  • Materials Science

Background:

  • Riparin-A possesses diverse pharmacological activities including antimicrobial, anti-inflammatory, and antioxidant effects.
  • Low aqueous solubility of Riparin-A limits its therapeutic application and bioavailability.
  • Development of novel drug delivery systems is crucial for enhancing Riparin-A's efficacy.

Purpose of the Study:

  • To develop a nanohybrid system of Riparin-A and Laponite.
  • To enhance the solubility and dissolution profile of Riparin-A.
  • To evaluate the cytotoxic potential of the developed nanohybrid system.

Main Methods:

  • Formation of the Riparin-A/Laponite hybrid system.
  • Characterization using X-ray powder diffraction, infrared spectroscopy, and thermal analysis.
  • Assessment of solubility, dissolution rate, and cytotoxicity.

Main Results:

  • The Riparin-A/Laponite nanohybrid demonstrated increased solubility and aqueous dissolution rate.
  • Characterization suggested amorphization of Riparin-A and altered thermal properties upon interaction with Laponite.
  • The nanohybrid system showed no cytotoxic activity against normal and tumorigenic cell lines.

Conclusions:

  • The Riparin-A/Laponite nanohybrid system shows significant promise for therapeutic applications.
  • This formulation may enhance the bioavailability and expand administration routes for Riparin-A.
  • Further development could lead to improved drug delivery of this bioactive compound.