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Vitiligo and Metabolic Syndrome: Systematic Review and Meta-Analysis
Joyce Xia1, Christina Melian1, William Guo2
1Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States.
This meta-analysis found a significant association between vitiligo and metabolic syndrome (MetS), with elevated fasting glucose and diastolic blood pressure in vitiligo patients. Dermatologists should monitor for MetS complications.
Area of Science:
- Dermatology
- Endocrinology
- Cardiology
Background:
- Metabolic syndrome (MetS) is linked to various skin conditions, but a quantitative analysis of its association with vitiligo is lacking.
- Understanding this link is crucial for comprehensive patient care.
Purpose of the Study:
- To quantitatively assess the association between vitiligo and metabolic syndrome (MetS) using a systematic review and meta-analysis.
- To determine the prevalence of MetS in individuals with vitiligo.
Main Methods:
- Systematic literature search of major databases (PubMed, Embase, Cochrane, Web of Science) up to August 2020.
- Inclusion of case-control and prospective cross-sectional studies.
- Meta-analysis of prevalence and association, examining MetS components, BMI, and lipid levels.
Main Results:
- Pooled prevalence of MetS in vitiligo patients was 29.6%.
- Vitiligo patients showed significantly elevated fasting glycemic index and diastolic blood pressure.
- A significant association between MetS and vitiligo was confirmed (P<.001).
Conclusions:
- The association between vitiligo and MetS has significant clinical implications.
- Dermatologists and healthcare providers should vigilantly screen vitiligo patients for MetS.
- Early detection and management of MetS can prevent severe cardiovascular complications.
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