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The rabbit ear-withdrawal test: a new analgesiometric procedure
Pharmacology, Biochemistry, and Behavior
|August 1, 1986
Summary
Morphine prolonged the ear-withdrawal reflex latency in rabbits. This finding supports the rabbit ear-withdrawal test as a valuable method for screening new pain relief compounds.
Area of Science:
- Pharmacology
- Neuroscience
- Pain Research
Background:
- The rabbit ear-withdrawal test is a model for assessing pain perception.
- Investigating the effects of analgesics requires reliable testing methods.
Purpose of the Study:
- To evaluate the effect of morphine on the rabbit ear-withdrawal reflex.
- To assess the utility of the rabbit ear-withdrawal test for screening analgesic compounds.
Main Methods:
- Rabbits were intravenously administered morphine.
- The latency to ear movement in response to radiant heat was measured.
Main Results:
- Intravenous morphine administration significantly prolonged the ear-withdrawal reflex latency in rabbits.
- The rabbit model demonstrated suitability for repeated and long-term testing.
Conclusions:
- The rabbit ear-withdrawal test is a viable and sensitive model for screening analgesic and anesthetic compounds.
- This model can aid in the development of novel pain management therapies.