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Updated: Jul 17, 2025

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Candida-bacterial cross-kingdom interactions.

Kara R Eichelberger¹, Saikat Paul², Brian M Peters³

¹Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.

Trends in Microbiology

|August 28, 2023

Summary

This summary is machine-generated.

Interactions between Candida albicans and bacteria impact its role as a commensal or pathogen. Understanding these cross-kingdom dynamics can reveal new antifungal treatments.

Keywords:

Candida albicans antifungal immunity cross-kingdom interactions polymicrobial infection

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Published on: January 13, 2016

Area of Science:

Microbiology
Immunology
Mycology

Background:

Candida albicans is a fungus that commonly colonizes humans but can cause infections.
The transition of C. albicans from commensal to pathogen is complex.
Cross-kingdom interactions, particularly with bacteria, significantly influence C. albicans.

Purpose of the Study:

To review the impact of C. albicans-bacteria interactions on host-microbe dynamics.
To explore how these interactions affect C. albicans pathogenesis and infection.
To identify opportunities for novel antifungal therapies based on cross-kingdom interactions.

Main Methods:

Literature review of studies on Candida albicans and bacterial interactions.
Analysis of research on polymicrobial communities and host immune responses.
Synthesis of findings related to microbial pathogenesis and dysbiosis.

Main Results:

C. albicans-bacteria interactions shape microbial community structure and host immunity.
Dysbiosis in these interactions can lead to C. albicans infections.
Cross-kingdom interactions offer insights into C. albicans virulence mechanisms.

Conclusions:

Understanding C. albicans interactions with bacteria is crucial for comprehending its dual role.
These interactions are key factors in the development of C. albicans infections.
Targeting cross-kingdom interactions presents a promising strategy for developing new antifungal agents.