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Progression in pediatric glaucoma: lessons learnt from 8 years' follow-up
Farideh Sharifipour1, Elahe Arasteh2,3, Maryam Hajizadeh2,3
1Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science and Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Medical Hypothesis, Discovery & Innovation Ophthalmology Journal
|August 29, 2023
Summary
Children diagnosed with pediatric glaucoma earlier and those with systemic diseases face higher progression risks. Early intervention and monitoring are crucial for managing this condition.
Area of Science:
- Ophthalmology
- Pediatric Medicine
- Genetics
Background:
- Pediatric glaucoma, a severe eye condition, often requires surgical intervention.
- Despite treatment, disease progression remains a concern in children.
- Identifying risk factors for progression is vital for effective management.
Purpose of the Study:
- To investigate the key risk factors associated with the progression of pediatric glaucoma.
- To enhance understanding of disease trajectory in young patients.
Main Methods:
- Retrospective cohort study of pediatric glaucoma patients (April 2009-March 2017).
- Inclusion criteria: regular follow-up for at least 1 year.
- Data collected: demographics, intraocular pressure (IOP), central corneal thickness (CCT), axial length (AL), cup-to-disc ratio (C/D ratio), corneal diameter, glaucoma type, age at diagnosis, and age at surgery.
Main Results:
- 32.5% of 83 eyes showed progression.
- Younger age at diagnosis and first surgery were significant risk factors for progression (P=0.046, P=0.012).
- Higher frequency of comorbid systemic disease (P=0.043) and increased number of surgeries (P=0.015) were associated with progression.
Conclusions:
- Younger age at diagnosis/surgery and comorbid systemic diseases increase pediatric glaucoma progression risk.
- Findings aid clinicians in counseling families about potential disease outcomes.
- Further prospective studies are recommended for confirmation.
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