Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly Programmable Liquid Crystalline Polyurethane/MXene Hybrids for Large-Strain, High-Work-Capacity Artificial Muscles.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Bone Marrow-Derived Macrophages' Response to Anisotropic Forces through Distinct Sensing and Transduction Pathways.

ACS applied materials & interfaces·2026
Same author

Topology-Engineered Hyperbranched Zwitterionic Polymer Enabling Robust Hydration Lubrication in Osteoarthritic Joints.

Biomacromolecules·2026
Same author

One-Pot Preparation of an Antioxidant, Anti-Inflammatory, and Analgesic Hydrogel for Oral Mucosal Lesions.

ACS applied materials & interfaces·2025
Same author

Injectable pH-Responsive Hydrogel Adapted to Gingival Crevicular Fluid Microenvironment for Periodontitis Therapy.

ACS applied materials & interfaces·2025
Same author

Fabricating Remote-Controllable Dynamic Ionomer/CNT Networks via Cation-π Interaction for Multi-Responsive Shape Memory and Self-Healing Capacities.

ACS applied materials & interfaces·2025

Related Experiment Video

Updated: Jul 17, 2025

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.7K

Shape Memory Polyester Scaffold Promotes Bone Defect Repair through Enhanced Osteogenic Ability and Mechanical

Rui Du1, Bin Zhao2, Kun Luo1

  • 1The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610064, China.

ACS Applied Materials & Interfaces
|August 29, 2023
PubMed
Summary

This study developed a novel bioactive, shape-memory bone scaffold using 4D printing for enhanced bone defect repair. The innovative scaffold promotes cell growth and bone regeneration, offering a promising clinical strategy.

Keywords:
4D printingbioactivebone defect repairshape memorytissue engineering

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.1K

Related Experiment Videos

Last Updated: Jul 17, 2025

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold
09:37

Fabrication of a Bioactive, PCL-based "Self-fitting" Shape Memory Polymer Scaffold

Published on: October 23, 2015

12.7K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.8K
Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
08:02

Fabrication of Decellularized Cartilage-derived Matrix Scaffolds

Published on: January 7, 2019

11.1K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Engineering

Background:

  • Traditional bone scaffolds face limitations like poor bioactivity and osseointegration.
  • Developing advanced scaffolds is crucial for effective bone tissue engineering and defect repair.

Purpose of the Study:

  • To fabricate a bioactive, shape-memory bone scaffold using 4D fused deposition modeling.
  • To enhance osteogenesis and bone regeneration for treating bone defects.

Main Methods:

  • Utilized a biodegradable polyester copolymer with poly(ε-caprolactone) for shape memory and poly(propylene fumarate) for bioactivity.
  • Employed 4D fused deposition modeling to create scaffolds with ~300 μm pores and tunable mechanical properties.
  • Conducted in vitro cell studies and in vivo experiments to evaluate scaffold performance.

Main Results:

  • The 4D printed scaffold exhibited shape memory properties and mechanical characteristics similar to spongy bone.
  • The scaffold significantly enhanced MC3T3-E1 cell adhesion and osteogenic differentiation in vitro.
  • In vivo studies demonstrated accelerated bone regeneration in defect sites with the shape-memory scaffold.

Conclusions:

  • The developed bioactive shape-memory scaffold is a promising strategy for clinical bone defect treatment.
  • The scaffold's ability to adapt to defect geometry and promote bone regeneration is a key advantage.
  • This technology offers a novel approach for substantial bone defects with irregular geometries.