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Poorly differentiated orbital neuroendocrine carcinoma
Yi Stephanie Zhang1,2, Marycon Jiro1,2,3, Melike Pekmezci1,4,5
1Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
This case highlights orbital neuroendocrine carcinoma, a rare cancer presenting with eye swelling and double vision. Early diagnosis and understanding varied presentations are crucial for managing this aggressive condition.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Orbital neuroendocrine carcinoma is a rare malignancy.
- It can present with varied symptoms mimicking other orbital diseases.
Observation:
- A 70-year-old male presented with painless bilateral eyelid edema and vertical diplopia.
- MRI revealed enlarged extraocular muscles and orbital fat stranding.
- Orbital biopsy confirmed poorly differentiated high-grade neuroendocrine carcinoma.
Findings:
- No systemic primary site was identified.
- The patient received carboplatin and etoposide chemotherapy.
- The patient unfortunately passed away from infection one month post-diagnosis.
Implications:
- Orbital neuroendocrine carcinoma requires a high index of suspicion due to its diverse presentations.
- Histological features are important for guiding metastatic evaluation.
- Further research into optimal treatment strategies for this rare tumor is warranted.
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