Related Experiment Video

Updated: Jul 17, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Circadian biology to advance therapeutics for mood disorders

Apoorva Bhatnagar1, Greg Murray2, Sandipan Ray3

  • 1Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, 502284, Telangana, India; Centre for Mental Health, Swinburne University of Technology, Melbourne, Victoria, Australia.

Trends in Pharmacological Sciences
|August 30, 2023
PubMed

Insights

New research explores circadian clock-based treatments for mood disorders, addressing suboptimal current medications. This review highlights targeting the circadian system, medication timing, and personalized approaches for better therapeutic outcomes.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Chronobiology

Background:

  • Mood disorders represent a significant global health challenge with existing treatments often being suboptimal.
  • Growing evidence links circadian and sleep dysfunction to the development of mood disorders.
  • Chronobiological pathways are emerging as a key focus for innovative mood disorder therapeutics.

Purpose of the Study:

  • To review contemporary evidence for circadian-clock-based therapeutics in mood disorders.
  • To explore three promising areas: targeting the circadian system, time-tailoring medications, and personalized treatment using circadian parameters.
  • To consider challenges in developing new circadian-informed pharmacotherapies.

Main Methods:

  • Review of contemporary scientific literature and evidence.
  • Analysis of mechanistic molecular advances related to the circadian system.
  • Examination of chronobiological parameters for treatment personalization.

Main Results:

  • Identification of three key areas for circadian-based therapeutics: direct circadian system targeting, chronopharmacology (time-tailoring), and personalized circadian parameter application.
  • Discussion of the potential of these approaches to overcome limitations of current mood disorder treatments.
  • Consideration of the scientific and developmental hurdles for these novel therapies.

Conclusions:

  • Circadian clock-based strategies offer promising avenues for innovative mood disorder pharmacotherapies.
  • Further research and development are needed to overcome challenges in translating these chronobiological insights into clinical practice.
  • Personalized and time-tailored treatments hold potential for improved efficacy in mood disorder management.
Keywords:
bipolar disorderchronomedicinecircadian rhythmdepressionmental healthpersonalized therapy

More Related Videos

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.8K
Circadian Entrainment of Drosophila Melanogaster07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

4.4K

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
87
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
278
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
34.7K
Understanding Sleep01:11

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
407
Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
177