Dynamic panoramic presentation of skin function after fractional CO₂ laser treatment

Fractional CO₂ laser, as a typical ablative laser, has been used to assist in the treatment of many skin diseases, such as photoaging, atrophic scar, hypertrophic scar, superficial pigmentation, vitiligo, and so on. However, the dynamic changes in skin function after fractional CO₂ laser treatment are still unclear. This study explored the changes in local skin function and possible regulatory mechanisms after fractional CO₂ laser treatment for 1, 3, 5, and 7 days through transcriptome high-throughput sequencing. The results showed that fractional CO₂ laser tended to transform the "lesions" into "normal skin", regulate the skin barrier, coordinate the rearrangement of collagen, enhance the local microvascular circulation, activate the immune system to secrete a large number of cytokines, and act as an auxiliary tool to assist drug transport. In conclusion, according to the basic principle of destruction before reconstruction, fractional CO₂ laser plays a key role of balancer in skin reconstruction.