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CKD and Rapid Kidney Function Decline During the COVID-19 Pandemic
Clarissa J Diamantidis1,2, David J Cook2,3, Cyd Kristoff Redelosa2
1Duke University School of Medicine, Durham, NC.
Kidney Medicine
|August 31, 2023
Summary
COVID-19 infection increased the risk of rapid kidney function decline in patients with chronic kidney disease (CKD). Close monitoring is crucial for CKD patients, especially those with COVID-19, to manage kidney health during the pandemic.
Area of Science:
- Nephrology
- Infectious Diseases
- Public Health
Background:
- The impact of COVID-19 on chronic kidney disease (CKD) patients remains unclear.
- Understanding kidney function trajectories in CKD during the pandemic is essential.
Purpose of the Study:
- To assess kidney function decline in CKD patients during the COVID-19 pandemic.
- To evaluate the specific impact of COVID-19 infection on kidney function in this population.
Main Methods:
- Retrospective cohort study using administrative claims and laboratory data (2018-2021).
- Propensity score matching compared COVID-19 infected and non-infected CKD patients (stages G3-4).
- Analyzed kidney function trajectories (eGFR) in prepandemic vs. pandemic periods.
Main Results:
- COVID-19 infection was associated with a higher risk of rapid kidney function decline (2.5% vs. 1.5%).
- Factors increasing rapid decline risk included Asian race, higher comorbidity index, advanced CKD, and prior rapid decline.
- Overall rapid kidney function decline rates did not significantly change between periods, but COVID-19 infection was a key risk factor.
Conclusions:
- COVID-19 infection significantly increases the odds of rapid kidney function decline in CKD patients.
- Close monitoring of kidney function is recommended for CKD patients, particularly those with COVID-19.
- Further research is needed on the long-term outcomes of pandemic-related kidney function decline.
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