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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
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Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

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Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

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Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

29
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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CKD and Rapid Kidney Function Decline During the COVID-19 Pandemic.

Clarissa J Diamantidis1,2, David J Cook2,3, Cyd Kristoff Redelosa2

  • 1Duke University School of Medicine, Durham, NC.

Kidney Medicine
|August 31, 2023
PubMed
Summary

COVID-19 infection increased the risk of rapid kidney function decline in patients with chronic kidney disease (CKD). Close monitoring is crucial for CKD patients, especially those with COVID-19, to manage kidney health during the pandemic.

Keywords:
CKDCOVID-19Chronic kidney diseaseoutcomespandemicrapid kidney function decline

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • The impact of COVID-19 on chronic kidney disease (CKD) patients remains unclear.
  • Understanding kidney function trajectories in CKD during the pandemic is essential.

Purpose of the Study:

  • To assess kidney function decline in CKD patients during the COVID-19 pandemic.
  • To evaluate the specific impact of COVID-19 infection on kidney function in this population.

Main Methods:

  • Retrospective cohort study using administrative claims and laboratory data (2018-2021).
  • Propensity score matching compared COVID-19 infected and non-infected CKD patients (stages G3-4).
  • Analyzed kidney function trajectories (eGFR) in prepandemic vs. pandemic periods.

Main Results:

  • COVID-19 infection was associated with a higher risk of rapid kidney function decline (2.5% vs. 1.5%).
  • Factors increasing rapid decline risk included Asian race, higher comorbidity index, advanced CKD, and prior rapid decline.
  • Overall rapid kidney function decline rates did not significantly change between periods, but COVID-19 infection was a key risk factor.

Conclusions:

  • COVID-19 infection significantly increases the odds of rapid kidney function decline in CKD patients.
  • Close monitoring of kidney function is recommended for CKD patients, particularly those with COVID-19.
  • Further research is needed on the long-term outcomes of pandemic-related kidney function decline.