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Red emissive carbon dots: a promising next-generation material with intracellular applicability
Khushboo Warjurkar1, Satyajit Panda2, Vinay Sharma1
1Department of Biosciences and Bioengineering, Indian Institute of Technology Jammu, Jagti, Jammu-180012, India. vinay.sharma@iitjammu.ac.in.
Journal of Materials Chemistry. B
|August 31, 2023
Summary
Red emissive carbon dots (RCDs) overcome limitations of traditional CDs for advanced biomedical imaging and therapy. RCDs offer deep tissue penetration and high contrast, paving the way for clinical applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Optical Imaging
Background:
- Carbon dots (CDs) are widely used in biomedicine for imaging and detection.
- Limitations of blue-green CDs include shallow penetration and photodamage.
- Red emissive CDs (RCDs) offer improved properties for biomedical applications.
Purpose of the Study:
- To review the applications of red emissive carbon dots (RCDs) in biomedicine.
- To highlight the advantages of RCDs over traditional CDs.
- To discuss the potential of RCDs for future clinical use.
Main Methods:
- Review of existing literature on RCDs in biomedical applications.
- Analysis of RCD properties such as emission, penetration, and biocompatibility.
- Synthesis of information on RCDs for bioimaging, therapy, and drug delivery.
Main Results:
- RCDs exhibit deep tissue penetration, minimal photodamage, and high imaging contrast.
- RCDs are effective in various applications including in vivo/in vitro bioimaging, photoacoustic imaging, and sensing.
- RCDs show promise in tumor therapy and drug delivery systems.
Conclusions:
- RCDs present a significant advancement over conventional CDs for biomedical applications.
- The unique properties of RCDs facilitate enhanced cellular and tissue imaging.
- Continued development of RCDs is expected to lead to near-future clinical translation.
