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Blood virome of patients with traumatic sepsis

Qingqing Mao1,2, Ying Liu3, Ju Zhang2

  • 1Clinical Laboratory Center, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China.

Virology Journal
|September 1, 2023
PubMed

Insights

Post-traumatic sepsis patients showed a predominant viral community of Anellovirus, with no significant changes after treatment. This highlights the need for rapid viral diagnostics in sepsis management.

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Sepsis, a life-threatening condition following severe trauma, particularly affects immunocompromised individuals.
  • While bacteria and fungi are common sepsis pathogens, viral infections are often overlooked.
  • Understanding the viral landscape in sepsis is crucial for effective treatment strategies.

Purpose of the Study:

  • To investigate the viral metagenomic profile in patients with post-traumatic sepsis.
  • To analyze changes in viral communities and loads before and after treatment.
  • To explore the potential for developing next-generation sequencing (NGS)-based viral diagnostic tools for sepsis.

Main Methods:

  • Blood samples were collected from eight post-traumatic sepsis patients.
  • Samples were analyzed pre-treatment and seven days post-treatment using viral metagenomic analysis.
  • Viral community composition and load were assessed.

Main Results:

  • Anellovirus was the predominant virus in the studied patient cohort.
  • Siphoviridae and Myoviridae were also identified viral components.
  • No statistically significant variations in viral community structure or viral load were observed between pre-treatment and post-treatment samples.

Conclusions:

  • Anellovirus is a significant component of the viral community in post-traumatic sepsis.
  • Current treatment approaches did not significantly alter the viral landscape in this cohort.
  • Developing rapid NGS-based diagnostics is essential for timely detection and management of viral infections in sepsis patients.
Keywords:
BloodMategenomicsSepsisViromeWounds and injuries

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