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Updated: Jul 17, 2025
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Published on: September 30, 2021
The Hallmarks of Liver Fluke Related Cholangiocarcinoma: Insight into Drug Target Possibility
Watcharin Loilome1,2, Nisana Namwat3,4, Apinya Jusakul5,4
1Department of System Biosciences and Computational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. watclo@kku.ac.th.
Abstract:
Cholangiocarcinoma (CCA) is a malignant tumor of the biliary tree that is classified into three groups based on its anatomic location: intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA). Perihilar CCA is the most common type and accounts for 50-60% of CCA cases. It is followed by distal CCA and then intrahepatic CCA that account for 20-30% and 10-20% of cases, respectively. This chapter discusses the hallmarks of liver fluke related CCA and explores insights into drug target possibilities.
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